Some have thought that the name might have its root in the greek word for river (potamus) - but it is more likely that it is a Europeanised version of the name of a tribe who lived in the Northern Neck area (to the South of Washington DC - near to Fredericksburg). This tribe was part of the Powhatan Confederacy (also known as the Virginia Algonquians). Other scholars have argued that the term means say the name means "place where people trade" or "the place to which tribute is brought".
The river runs for approximately 383 miles - from the Fairfax Stone in West Virginia to Point Lookout, Maryland.